In Vitro Interactions of Echinocandins with Triazoles against Multidrug- Resistant Candida auris

We determined the in vitro interactions between echinocandins and
azoles against 10 multidrug-resistant Candida auris strains by use of a microdilution
checkerboard technique. Our results suggest synergistic interactions between micafungin
and voriconazole with fractional inhibitory concentration index (FICI) values
of 0.15 to 0.5, and we observed indifferent interactions when micafungin was combined
with fluconazole (FICI, 0.62 to 1.5). Combinations of caspofungin with fluconazole
or voriconazole exhibited indifferent interactions. No antagonism was observed
for any combination.