Nasuhi Pur, F (2020) Calix[4]API‑s: fully functionalized calix[4]arene‑based facial active pharmaceutical ingredients. Molecular Diversity. pp. 1-12.
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Abstract
This mini-review covers 25 fully functionalized facial calix[4]arene-based symmetrical and conical cyclic tetramers with significant (comparable to established therapeutic agents) anticancer and anti-infective activities. The main role of the calixarene scaffold in these calix[4]arene-based active pharmaceutical ingredients (calix[4]API-s) is to replicate embedded phenolic units in the cyclic tetramers. So, probably owing to the multivalency, facial, conical structures of calix[4]API-s and synergistic effect of their four replicated units, they can be considered as effective bioactive agents.
| Item Type: | Article |
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| Uncontrolled Keywords: | Calix[4]arene · Active pharmaceutical ingredient · Anticancer · Anti-infective · Cyclic tetramer |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 02 Feb 2020 06:10 |
| Last Modified: | 02 Feb 2020 06:10 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/5833 |
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