The effect of lycopene in egg shell membrane guidance channel on sciatic nerve regeneration in rats

Farjah, G.H and Zirak Javanmard, M and Mohammdzadeh, S (2020) The effect of lycopene in egg shell membrane guidance channel on sciatic nerve regeneration in rats. Iran J Basic Med Sci, 23. pp. 527-533.

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Abstract

Peripheral nerves are commonly damaged. Although the nerve autograft still subsists the gold standard in surgery of nerve injury gaps, it has severe detriment. The egg shell membrane (ESM) is a natural material,which has a great potential in practice. The aim of this surveywas to appraise the effect of lycopene and the ESM nerve guidance channel on sciatic nerve regeneration. Materials and Methods: In this study, 32 male rats were randomized into four groups: sham surgery, autograft, ESM+ dimethyl sulfoxide (DMSO), and ESM+lycopene. One centimeter of sciatic nerve was removed, and the gap was grafted by ESM channel or autograft. The sciatic function index (SFI) was evaluated at days 7, 21, 30, 49, 60 and 90 after surgery. Nerve regeneration and gastroknemius muscle fibers were evaluated at days 30 and 90 after surgery by withdrawal reflex latency (WRL), histology and immunohistology assessments. Results: At 49, 60 and 90 days after surgery, the mean SFI in ESM+lycopene group was significantly great number er of thanmyelinat ESM+DMSO ed axgr onsoupin (P< ESM+l 0.05). y On copenedayand90,aut theogrmean aft groups musclewer fiber e diamet significantl ersyand great theermean than ESM+DMSO group (P<0.05). In addition, the mean WRL was significantly lower in ESM+lycopene group than in the ESM+DMSO group 90 days after surgery (P<0.05). beneficial Conclusion: for tr The r eating esults of peripher thisal stud nervye show damages. that

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