Avizheh, L and Fathi Azarbayjani, A and Diba, K and Peirouvi, T (2019) Electrospun wound dressing as a promising tool for the therapeutic delivery of ascorbic acid and caffeine. Ther Deliv, 10 (12). pp. 757-767.
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Abstract
Aim: The aim of this work is to formulate a wound dressing for the delivery of ascorbic acid and caffeine. Method: A wound dressing was developed from electrospun nanofiber containing ascorbic acid and caf- feine. In vitro drug release was performed at 25◦Cand32◦C.Wound healing activity of the nanofiber mats was tested in vivo using rat model with skin excision. Antifungal activity of the dressing was tested on Candida albicans using the disc diffusion method. Results & conclusion: Zone of inhibition was 6.7 mm for caffeine dressing; however, inhibition zone increased to 16.7 mm for samples containing both caffeine and ascorbic acid. Animals treated with ascorbic acid showed collagen deposition and very few fibroblast cells. Blood vessels and fibroblasts were increased in caffeine-loaded dressings compared with the ascorbic acid group. The findings of the present work suggest the benefits of topical ascorbic acid and caffeine for its high wound healing effects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ascorbic acid • caffeine • electrospinning • nanofiber • topical drug delivery • wound healing |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 07 Mar 2020 06:18 |
| Last Modified: | 07 Mar 2020 06:20 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/5891 |
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