Complications of Antiepileptic Drugs in Hospitalized Patients in Shahid Motahari Hospital of Urmia from 2010 till the end of 2016

Seizure is a common neurological disease with many therapies, especially antiepileptic drugs being used to treat it. Any adverse effects caused by taking antiepileptic drugs are called antiepileptic side effects. The purpose of this study was to evaluate the side effects of antiepileptic drugs in patients admitted to Shahid Motahari Hospital of Urmia from 2010 until the end of 2016.
Materials & Methods: This descriptive study was conducted after the approval of the Ethics Committee of Urmia University of Medical Sciences. In this study, 100 epileptic children with complications of antiepileptic drugs admitted to Motahari Pediatric Hospital of Urmia from 2010 to 2016 were studied. The sampling method was census using the keyword drug reaction in patient files. The information was collected through a checklist, which was completed by the project manager based on the information in the patient's file. The checklist consisted of 3 sections. The first part included demographic information of patients including age and sex; the second part included targeted information including the number of seizures, type of anticonvulsant drug used; and the third part included targeted information including drug side effects in these patients.
Results: The mean weight SD of the studied patients was 40.09 /1 1.94 kg with a median of 41.50 kg. Most of the adverse events observed in the studied patients were related to skin complications with the frequency of 52 patients (52%). The most common adverse events observed were within the age range of 9 to 10 years with a frequency of 16 patients (16%). Also, there was no significant relationship between the side effects of epileptic drugs and the age of the patients (p = 0.844).
Conclusion: The renal side effects of antiepileptic drugs in males were higher than females, and the skin and liver complications were higher in females, and the most common side effects were observed within the age range of 9 to 10 years. It also has a direct relationship with the duration of drug side effects. Compared to sodium valproate, Phenobarbital has more side effects in children