Computed Tomography Severity Grading of Chronic Obstructive Pulmonary Disease based on Volumetric Assessment of Inspiratory and Expiratory Scans

To determine attenuation threshold for detection and quantification of air trapping in obstructive airway disease.
Quantify airway dysfunction in patients of obstructive airway disease & its correlation with pulmonary function tests.
Materials & Methods: Paired HRCT scans of 48 patients were done and correlated with Pulmonary Function Tests taken within 2
weeks of the study. Threshold attenuation value on expiratory scan that signifies air trapping was obtained by correlating relative
volumes with PFT parameters (PEF 25-75% & RV/TLC). The lung volumes at this threshold were then correlated with PFT values
signifying airway dysfunction (FEV1, FEV1/FVC and PEF 25-75%) and airway dysfunction was then quantified based on these
volumes.
Results: Maximum correlation of PFT parameters signifying air trapping is with relative volume of limited lung at -850HU (l850)
(p<0.005) which was taken as the threshold for air trapping. Using this threshold (-850HU), we calculated the relative volume change
of limited and whole lung (l850 & t850) and expiratory relative volume of limited and whole lung (ERV l850 & ERV t850). Significant
correlation was seen between l850 and PFT parameters signifying airway dysfunction (p<0.005). A severity classification of obstructive
airway disease was formulated based on l850 and classified patients into mild (l850<-30%), moderate (l850= -20 - -30%), severe (l850
=-10 - -20%), and very severe (l850 > -10%).
Conclusion: l850 can be used as a CT parameter to quantify airway dysfunction irrespective of presence or absence of emphysema.
Severity classification of obstructive airway disease was formulated based on l850.