THE EFFECT OF TWO MONTHS OF CHIA SUPPLEMENTATION ON INFLAMMATORY AND ANTI-INFLAMMATORY RESPONSES IN WISTAR DIABETIC MALE RATS

Nabilpour, M and Seifi, F and Sadeghi, A (2021) THE EFFECT OF TWO MONTHS OF CHIA SUPPLEMENTATION ON INFLAMMATORY AND ANTI-INFLAMMATORY RESPONSES IN WISTAR DIABETIC MALE RATS. Studies in Medical Sciences, 32 (2). pp. 116-123.

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Abstract

Increased inflammation is a consequence of diabetes. Accordingly, the use of herbal medicine as a solution has been suggested. The objective of this study was to evaluate the effect of two months of chia supplementation in conjunction with inflammatory and anti-inflammatory responses in male Wistar diabetic rats. Materials & Methods: 36 diabetic rats were randomly assigned to 3 equal groups (control group, diabetes group, diabetes + chia group) and were subjected to 8 weeks of supplementation. Interleukin-1 and interleukin-13 were measured in soleus muscle tissue to examine the inflammatory and antiinflammatory indicators. ANOVA and Tukey's post hoc test were used for data analysis. Results: Although chia supplementation had aggravating effects on IL-1ß compared with the diabetic group, this effect was not statistically significant (p = 0.99). Also, IL-13 protein expression increased significantly in the diabetic control group by about 51% (p = 0.001), and in the diabetic group with chia supplementation by about 50% (p= 0.001) compared to the healthy control group. There was no significant difference between the two groups. Conclusion: It seems that two months of chia supplementation with this dose and period of consumption could not have a positive effect on anti-inflammatory factors in male diabetic rats. Confirmation of this finding requires further research in this area

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