EVALUATION OF IN VITRO ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF NANOEMULSIONS SYNTHESIZED BY ARTEMISIA AUCHERI BOISS ESSENTIAL OIL

Irani, M and Ardalan, T and Homayouni Tabrizi, M (2021) EVALUATION OF IN VITRO ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF NANOEMULSIONS SYNTHESIZED BY ARTEMISIA AUCHERI BOISS ESSENTIAL OIL. Studies in Medical Sciences, 32 (2). pp. 134-143.

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Abstract

Due to the threat to human health with diseases related to oxidative stress and infectious diseases, today the use of natural compounds and changes in them to improve their effectiveness has received much attention. The aim of this study was to evaluate the antioxidant and antimicrobial activity of nanoemulsions prepared from Artemisia aucheri Boiss essential oil (AABEONE). Materials & Methods: The AABEO-NE was synthesized by ultrasound method and formulated with 9 ml of Tween 80, 1 ml of polyethylene glycol, 3 ml of Artemisia essential oil, and 87 ml of distilled water. The antioxidant activities of nanoemulsions were investigated using various biochemical methods such as DPPH (1,1-diphenyl-2-picryl-hydrazyl) and ABTS (2,2-azinobis (3-ethyl benzothiazoline-6- sulfonic acid). Then, the antibacterial activity of nanoemulsion was evaluated by the disk diffusion (DD) method. Results: The data obtained from this study showed that nanoemulsions synthesized by Artemisia essential oil have a high potential for inhibiting DPPH radicals (IC50 = 80μg / ml) and ABTS (IC50 = 79μg / ml). The existence of a growth inhibition zone (10mm) in the sample treated with AABEO-NE confirmed the antibacterial effects of AABEO-NE Conclusion: According to the results, AABEO-NE can be used as a safe, natural, and effective antibiotic for bacterial infections caused by S. aureus and also, this formulation can be used due to its high antioxidant effects in the treatment of diseases related to oxidative stress

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