Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds

Khezri, KH and Shahi, SH and Rahbar Saadat, Y and Maleki Dizaj, S and Sharifi, S and Ahmadian, E and Lotfipour, F and Dalir Abdolahinia, E and Eftekhari, A (2021) Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds. Stem Cells International. pp. 1-9.

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Abstract

Studies have shown that a range of therapeutic effects of various herbal medicines can be identified [1–4]. Curcumin (diferuloylmethane) as a bioactive hydrophobic polyphenolic ingredient is obtained from Curcuma longa (turmeric) rhizome. Recently, it received significant attentions as a medicinal plant due to its unique therapeutic benefits including antipathogenic, antioxidant, anti-inflammation, antiangiogenic, anticancer, and antidiabetic effects, as treatment for central nervous system and cardiovascular disorders, in skin diseases and the cosmetic industry, lung diseases, antiatherosclerotic, ophthalmic, cystic fibrosis and osteoporosis, beta-thalassemia, etc. [5–8]. Also, it was reported as a valuable material in nutritional supplements due to the pleiotropic pharmacological properties [9]. Despite its multitarget biological effects, there are limitations to its clinical use due to its low absorption, bioavailability, and short half-life. Recently, several nanoparticles such as solid lipid nanoparticles, nanostructured lipid carriers, liposomes, micelles, nanogels, and magnetic nanoparticles are developed as novel and potential therapeutic strategies to improve therapeutic effects of various drugs such as curcumin [5–11]. Various investigations have demonstrated that novel systems of curcumin and stem cell differentiation have wonderful therapeutic potential against various bonerelated diseases [12]. An enhancement in adipocyte number in obesity can be the result of extreme differentiation of mesenchymal stem cells (MSC) to cell lineages of adipose.

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