Acute systemic infusion of bupropion decrease formalin induced pain behavior in rat

The chronic pain can disturb physical, psychological, and social performances. Analgesic agents are widely
used but some antidepressants (ADs) showed analgesia also. Bupropion is using for smoke cessation but it can
change morphine withdrawal signs such as pain. This study tested the acute systemic effect of bupropion on
formalin induced pain behavior in rats.
Methods:
Wistar male healthy rats were divided into 7 groups (control, sham, and 5 treated groups with 10, 30, 90,
120, and 200 mg/kg of bupropion, i.p.). The bupropion injected 3 hours prior to formalin induced pain behavior.
Formalin (50 μl, 2.5%) was injected subcutaneously in dorsal region of right hindpaw in all animals. Nociceptive
signs were observed continuously on-line and off-line each minute. Common pain scoring was used for pain
assessment.
Results:
The analysis of data by one-way ANOVA showed that bupropion can reduce pain scores in the second phase
but not in first phase. Bupropion decreased the licking/biting duration significantly in first and second phase
of formalin test.
Conclusions:
The results showed that bupropion has analgesic effects at systemic application. The change of second phase
of the pain behavior was significant and it revealed that central mechanisms involve in bupropion analgesia