INVESTIGATION OF THE EXPRESSION LEVEL OF MIR-195 AS A POTENTIAL BIOMARKER IN THE PLASMA OF GASTRIC CANCER PATIENTS IN GUILAN PROVINCE

Asadi Rahmani, F and Saeidi Saedi, H and Ranji, N (2021) INVESTIGATION OF THE EXPRESSION LEVEL OF MIR-195 AS A POTENTIAL BIOMARKER IN THE PLASMA OF GASTRIC CANCER PATIENTS IN GUILAN PROVINCE. Studies in Medical Sciences, 32 (5). pp. 365-375.

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Abstract

Gastric cancer is one of the five most common cancers in Iran, the sixth most common cancer in the world, and the second cause of cancer-related death worldwide. Failure to diagnose gastric cancer in early stages suggests the need to find potential biomarkers. This study aimed to evaluate the miR-195 expression as a potential biomarker in the plasma of gastric cancer patients in Guilan province. Materials & Methods: In this case-control study, the Q-RT-PCR method was used to evaluate the expression level of miR-195 in the plasma of 25 patients with gastric cancer and 25 normal individuals. The relationship between the expression level of miR-195 and clinicopathologic features was evaluated using the ANOVA test. The receiver operating characteristic (ROC) and area under the curve (AUC) were used to evaluate the miR-195 as a potential biomarker to discriminate cancerous from non-cancerous states of the samples. Results: Our analysis showed that miR-195 was significantly downregulated in gastric cancer patients compared to the normal individuals (p˂0.05). The AUC value of ROC analysis was 0.7325±0.008 (p=0.0119) with the sensitivity of 51.7% and specificity of 71.8%. Conclusion: Downregulation of miR-195 in gastric cancer patients and ROC analysis suggested that miR-195 can be introduced as a potential biomarker in the diagnosis of gastric cancer in Guilan province

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