Mota, A and Aboutalebi Vand Beilankouhi, E and Mirzamohammadi, F and Valilo, M and Khodabandeh, Z and Mohammad Alizadeh fard, H (2021) INVESTIGATION OF PARAOXONASE1 ACTIVITY RATIO TO ARYL ESTERASE OF PARAOXONASE 1 ENZYME AND FREQUENCY OF NACETHYLTRANSFERASE- 2 ENZYME POLYMORPHISMS IN PATIENTS WITH PARKINSON'S DISEASE: A CASE-CONTROL STUDY. Studies in Medical Sciences, 32 (6). pp. 399-407.
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Abstract
Parkinson's disease is the second most commonly diagnosed neurological disease after Alzheimer's disease. Paraoxonase 1 enzyme is an antioxidant enzyme with two paraoxonase and aryl esterase activity, and the change in activity and concentration of this enzyme can contribute to Parkinson's disease. The N-acetyltransferase enzyme plays an important role in the detoxification of organophosphates, in which the N-acetyltransferase 2 enzyme plays an important role. The aim of this study was to evaluate the paraoxonase activity ratio to aryl esterase activity of paraoxonase enzyme and the frequency of N-acetyltransferase 2 enzyme polymorphisms in patients with Parkinson's disease. Materials & Methods: In this case-control study, 80 cases (40 patients with Parkinson's disease and 40 control subjects) were studied. N-acetyltransferase-2 polymorphisms by the PCR-RFLP method were investigated using the relevant bound restriction enzymes. The serum level of paraoxonase 1 was determined by ELISA and enzyme activity of paraoxonase 1 was measured with spectrophotometric. Results: The ratio of paraoxonase to Aryl esterase did not show any significant difference between the two groups (p >0.05). Significant differences were observed in the frequency of m1 polymorphism genotypes between control and patient groups (p <0.05). However, the prevalence of polymorphism genotypes m1 and m2 between the two groups did not show a significant difference (p> 0.05). Conclusion: The results of this study showed that three N-acetyltransferase 2 polymorphisms, m1 polymorphism, as well as a decrease in serum levels and paraoxonase 1 activity, may contribute to the pathogenesis and etiology of Parkinson's disease
| Item Type: | Article |
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| Uncontrolled Keywords: | Parkinson's disease, gene polymorphism, paraoxonase 1, N-acetyltransferase 2 |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 17 Oct 2021 06:35 |
| Last Modified: | 17 Oct 2021 06:35 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/6331 |
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