Evaluation of Antioxidant and Antibacterial Effects of PLGA Nanoparticles Loaded with Rapeseed Pollen Extract

Background & Aims: In this study, the antioxidant and antibacterial capacity of PLGA nanoparticles containing rapeseed extract (REPNP)
was investigated.
Materials & Methods: Three various methods including Disk Diffusion (DD), Minimal Inhibitory Concentration (MIC), and Minimum
Bactericidal Concentration (MBC) were used to evaluate the antibacterial effects of synthesized nanoparticles against different strains
of bacteria. The inhibition capacity of ABTS and DPPH free radicals was measured to evaluate the antioxidant power of RE-PNP.
Results: The results showed that the RE-PNP have the potential to inhibit DPPH radicals (IC50 = 500μg / ml) and ABTS (IC50 = 1000μg
/ ml). The inhibitory effect of RE-PNP on the growth of Staphylococcus aurous and Micrococcus luteus was confirmed by the growth
inhibition zone 8 and 15 in the disk diffusion model.
Conclusion: According to the results, RPE-PNPs can be used as a safe, natural, and effective antibiotic for bacterial infections caused
by Staphylococcus aureus and Micrococcus luteus and also, this formulation can be used due to its antioxidant effects in treatment of
oxidative stress-related diseases.