Evaluation of serum oxidative stress markers in women with leiomyoma

Background & Aims: Background: One of the most common benign tumors that arise from the smooth muscles of the uterine wall is
leiomyoma. In this study, the levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) were assessed in leiomyoma
patients and compared with healthy individuals.
Materials & Methods: In this case-control study, 50 women with leiomyoma and 50 healthy women were selected as case and
control groups, respectively. ELISA method was used to measure MDA and TAC.
Results: The results showed that the serum level of MDA in leiomyoma patients increased significantly, as compared to healthy
individuals (0.52±1.48 vs. 0.65±1.3), while that of TAC had a significant reduction in patient group compared to healthy individuals
(151±151 vs. 466±212).
Conclusion: Our findings show a relationship between leiomyoma and oxidative stress indicators.