Asl, S.S and Pourheydar, B and Dabaghian, F and Nezhadi, A and Roointan, A and Mehdizadeh, M (2013) Ecstasy-induced caspase expression alters following ginger treatment. Basic and Clinical Neuroscience, 4 (4). pp. 51-55.
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Abstract
Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell death. Herein, we studied the protective effects of ginger on MDMA- induced apoptosis. Methods: 15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. Brains were removed to study the caspase 3, 8, and 9 expressions in the hippocampus by RT-PCR. Data was analyzed by SPSS 16 software using the one-way ANOVA test. Results: MDMA treatment resulted in a significant increase in caspase 3, 8, and 9 as compared to the sham group (p<0.001). Ginger administration however, appeared to significantly decrease the same (p<0.001). Discussion: Our findings suggest that ginger consumption may lead to the improvement of MDMA-induced neurotoxicity
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 2 |
| Uncontrolled Keywords: | Apoptosis, Ginger, MDMA, Caspase. |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 30 Jul 2017 04:55 |
| Last Modified: | 11 Jun 2019 05:41 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/763 |
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