Anti-oxidative effect of Lipoic acid on cholestasis induced crebellum toxicity

Cholestasis is a common pathophysiological process in many human diseases leading to the accumulation
of toxic bile salts within the liver. Accumulation of bile acids may cause injury in different organs through oxidative
pathway. Lipoic acid could be a potential therapeutic agent in the controlling different disorders that an imbalance of
the cellular oxidoreductive status. The aim of this study was to evaluate anti oxidative effect of LA on cerebellar
tissue after bile duct ligation in rats. forty five adult male wistar rats were randomly assigned to three groups each
containing fifteen rats as follows: sham operation (SO) (control), bile duct ligation (BDL), and BDL+LA (25mg/kg).
After fourteen day’s cerebellar tissue sampled for pathologic and biochemical studies. Levels of SOD and GPx
antioxidant enzymes were higher in BDL+LA group comparing to BDL group significantly (P<0.05). MDA levels
were higher in BDL group comparing to BDL+LA group significantly (P<0.05). In our study LA treatment in BDL
rats improved cellular SOD and GPx levels and reduced MDA levels in BDL+LA group comparing to BDL group.
The findings of our present study showed that LA, with its potent free radical scavenging and antioxidant properties,
seems to be a highly promising agent in protecting cerebellar tissue against oxidative damage