Synthesis of 5-(4-aminophenyl)-2-(arylamino)-1,3,4-thiadiazoles and their schiff base derivatives as antimycobacterial agents

Dilmaghani, K.A and Jazani, N.H and NasuhiPur, F and Shokoufeh, N and Ghadiri, F and Fakhraee, F.M (2012) Synthesis of 5-(4-aminophenyl)-2-(arylamino)-1,3,4-thiadiazoles and their schiff base derivatives as antimycobacterial agents. Chemistry of Heterocyclic Compounds, 48 (2). pp. 362-367.

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Abstract

The condensation reaction of 5-(4-aminophenyl)-N-aryl-1,3,4-thiadiazol-2-ylamines with salicyl-aldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde, 5-bromosalicylaldehyde, 5-chlorosalicyl-aldehyde, 4-methoxybenzaldehyde, 3-nitrobenzaldehyde, and 4-nitrobenzaldehyde results in series of new Schiff bases. The synthesized compounds were tested for their antimicrobial efficiency against Mycobacterium smegmatis PTCC 1307 in vitro. All compounds showed significant antiproliferative activity against M. smegmatis

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: salicylaldehyde, 1,3,4-thiadiazole, in vitro, Mycobacterium smegmatis, Schiff base
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email gholipour.s@umsu.ac.ir
Date Deposited: 06 Aug 2017 06:02
Last Modified: 03 Jun 2019 05:48
URI: http://eprints.umsu.ac.ir/id/eprint/990

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