EFFECT OF FULLERENE NANOPARTICLES ON BRAIN INFARCTION AND HISTOPATHOLOGICAL CHANGES DURING TRANSIENT AND FOCAL CEREBRAL ISCHEMIA IN RAT

Aryafar, M and Taghi Mohammadi, M (2016) EFFECT OF FULLERENE NANOPARTICLES ON BRAIN INFARCTION AND HISTOPATHOLOGICAL CHANGES DURING TRANSIENT AND FOCAL CEREBRAL ISCHEMIA IN RAT. The Journal of Urmia University of Medical Sciences, Vol. 27(8), November 2016, 27 (8). pp. 672-682.

[img]
Preview
 Text
article A-10-2421-1.pdf
Download (1MB) | Preview

Abstract

According to the recent studies, fullerene nanoparticles have a potent scavenging property for free radicals in biological environments. Since reactive oxygen species (ROS) is a fundamental mechanism of brain damage in stroke, we aimed to evaluate the neuroprotective effects of fullerene nanoparticles on ischemia-induced brain injuries in experimental model of stroke. Materials & Methods: Experiment was performed in three groups of rats (N=28): Sham, Control ischemia, and Ischemic treatment. Ischemia was induced by 90 min middle cerebral artery occlusion (MCAO) followed by 24 hours reperfusion. Rats received fullerene (5 mg/kg, intraperitoneally) 60 min before induction of MCAO. Cortical and striatal infarction (TTC staining), and histopathological alterations were assessed 24 hours after termination of MCAO. Results: MCAO induced brain infarction in cortical (307±16 mm3) and striatal (115±21 mm3) areas concomitant increase the histopathological damages. Administration of fullerene significantly reduced the infarction in cortical (166±15 mm3) and striatal (54±7 mm3) areas 45% and 53%, respectively. Also, fullerene decreased the mortality rate of ischemic treated rats (33.33%) compared to ischemic nontreated rats (9.09%) in accompany with the reduction of histopathological damages. Conclusion: It is concluded that fullerene nanoparticles, as a potent antioxidant factor, effectively reduce ischemia-induced brain damage and prevent neurodegeneration possibly through scavenging property of free radicals

Item Type: Article
Uncontrolled Keywords: Fullerene, Oxidative stress, Brain infarction, Neurodegeneration, Ischemic stroke
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email gholipour.s@umsu.ac.ir
Date Deposited: 25 Sep 2017 08:31
Last Modified: 21 Sep 2019 06:56
URI: http://eprints.umsu.ac.ir/id/eprint/3019

Actions (login required)

View Item View Item
Urmia University of Medical Siences Repository is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.