INVESTIGATING THE EFFECTS OF LOW FREQUENCY ELECTROMAGNETIC FIELD ON MCF-7 CANCER CELL LINE

Breast cancer is the most common cancer in women. The aim of this study was
to investigate the effects of electromagnetic field on MCF-7 cancer cell line.
Materials & Methods: MCF-7 cell lines and L929 cell line were cultured in RPMI medium that
contain fetal bovine serum and antibiotics. Cells for three hours were exposed to 50 Hz
electromagnetic field with intensities of 50, 200 and 400 Gauss. Growth and proliferation and
morphological changes were photographed by inverted microscope. Cell viability was quantitated by
MTT assay. The obtained data were statistically analyzed by SPSS software and compared with each
other by ANOVA and post hoc Tukey.
Results: Viability percent of MCF-7 (87.985±5.38) and L929 (93.726±4.28) cell line that were vicinity
of electromagnetic field with intensity of 50 gauss was not significantly compared to control. Viability
percent of MCF-7 (41.342±8.27) and L929 (44.649±3.39) cell line that were vicinity of
electromagnetic field with intensity of 200 gauss was significant compared to control. Viability
percent of MCF-7 (24.381±5.98) and L929 (30.627±7.55) cell line that were vicinity of
electromagnetic field with intensity of 400 gauss was significant compared to control.
Conclusion: Electromagnetic field with frequency of 50 Hz and intensities of 200 and 400 Gauss was
inhibitory effect on the growth and proliferation of MCF-7 and L929 cell line