STUDY OF SERUM CYSTATIN C & CREATININE AS A RELIABLE MARKER FOR DIAGNOSIS OF IMPAIRED RENAL FUNCTION IN HYPERTENSIVE PATIENTS

Amirrasouli, H and Kazerouni, F and Azimi, M (2013) STUDY OF SERUM CYSTATIN C & CREATININE AS A RELIABLE MARKER FOR DIAGNOSIS OF IMPAIRED RENAL FUNCTION IN HYPERTENSIVE PATIENTS. The Journal of Urmia University of Medical Sciences, 24 (4). p. 250.

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Abstract

In the past serum creatinine concentration was used as one of the important markers for early detection of kidney disorders, however recent studies suggest serum cystatin C to be a better marker. Therefore in this study we compared the diagnostic value of cystatin C with serum creatinine to evaluate kidney function in patients with high blood pressure. Materials & Methods: This clinical trial study was conducted on high blood pressure patients referring to Mehrad hospital during 1387-1389 for checking their kidney function. Cobasmira automated analyzer was used to determine serum creatinine. The serum cystatin C was measured using ELISA method. The glomerular filtration rate was determined by measuring 24hr creatinine clearance. Positive and negative predictive value, sensitivity and specificity of cystatin C and creatinine were determined. Results: We studied 35 patients with high blood pressure (20 men and 15 women mean age, 49±11). This research work showed that positive predictive value and negative predictive value of creatinine were 94.3% and 31% respectively. And for cystatin C, were 92.3% and 44% respectively. The false positive and negative result for serum creatinine method were 2.8% and 31.4% and for cystatin C were 5.7% and 14.2% respectively. Total accuracy of cystatin C was 90% and creatinine was 65.8%. Finally based on results obtained from this study cystatin C had a sensitivity of 82 % and specificity of 57% and serum creatinine had sensitivity of 62 % and specificity of 41% for detecting crcl<78 ml/min/1.73m2. Conclusion: It seems that measurement of serum cystatin C can be applied to detect the reduction of kidney function in the primary stages of kidney disorder.

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