ایلخانی زاده, بهروز and شهابی, شهرام and بهجتی, غلامرضا and نوروزی نیا, فرحناز and فرخ اسلاملو, محمد حسین and محمد حسن, زهیر (2009) FRACTAL STUDY ON NUCLEAR BOUNDARY OF CANCER CELLS IN URINARY SMEARS. J Urmia Univ Med Sci., 20 (2). pp. 104-110.
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Abstract
Cancer is a serious problem for human being. A necessary prerequisite for any therapeutic modality is early diagnosis. Fractal dimension measurement of nuclear boundary of cancer cells can be used as a feature extraction in the field of automated cancer diagnosis. Materials & Methods: 41 positive urine cytology and 33 negative ones were selected randomly. Digitalized images prepared using objective 100X and a digital video head preprocessed subsequently and the fractal dimension of nuclear boundaries was measured by a software. Results:�Findings revealed a statistically significant difference between fractal dimensions of nuclear boundaries of cancerous versus non-cancerous in urinary smears. Selecting a proper cut off point (1.732 ± 0.006 in this study) can discriminate malignant and non-malignant epithelial cells in urinary smears. Conclusion: Based on diagnostic accuracy measures (sensitivity and specificity), probability of disease measures (predictive value of a positive and negative test results), and likelihood ratio of positive and negative tests, it seems fractal dimension of nuclear cell boundaries in urinary smears can be used as a feature extraction in the field of automated cancer diagnosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Automated cancer diagnosis, Screening machine design, Fractal dimension |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 03 Jan 2018 07:05 |
| Last Modified: | 03 Jan 2018 07:05 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/3747 |
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