EFFECTS OF CROCIN FOLLOWING INDUCTION OF HYPOXIA MODEL ON AVOIDANCE MEMORY AND MOTOR ACTIVITY IN YOUNG RATS

Eskandarian, A and Fatemi Tabatabaei, S.R and Ghotbeddin, Z and Jamshidian, J (2018) EFFECTS OF CROCIN FOLLOWING INDUCTION OF HYPOXIA MODEL ON AVOIDANCE MEMORY AND MOTOR ACTIVITY IN YOUNG RATS. The Journal of Urmia University of Medical Sciences, 28 (12). pp. 826-836.

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Abstract

Hypoxia is the most common cause of seizures in the neonatal period. Seizure
induced by hypoxia cause permanent increases in excitability of neurons and by changing in activity
and synaptic plasticity leads to memory impairment. Crocins (Crocus sativus L.) is a water-soluble
carotenoid and is the most important active components of saffron. Most studies indicate that crocin
have important role in improving learning, memory and motor activity. In this work we assessed the
effect of crocin following epileptic model by hypoxia on passive avoidance memory and motor activity
in young rat.
Materials & Methods: In this study, 40 young rats (Wistar) 10-12 years old (18–22 g) maintained at
room temperature 23±2. Rats were divided into four experimental groups: sham, crocin, hypoxia only,
submitted to hypoxia followed by crocin treatment. For hypoxia induction rats placed in hypoxia
container with 7% O2 and 93% N2 for 15 minutes. In crocin group, rats received crocin (30mg/kg for
21 days) after their lactation period. Finally, passive avoidance memory, balance and motor activity
were assessed respectively by shuttle box, rotarod and open field instruments.
Results: A decreased step through latency and increased time spent in dark room was observed in
passive avoidance test after hypoxia (p<0/05), which could be inhibited by posttreatment with crocin.
Hypoxia also disrupted balance and motor activity in the rotarod and open field test (p<0/05), which
could be inhibited by treatment with crocin.
Conclusion: Results of this study indicated that hypoxia impairs passive avoidance learning, balance
and motor activity and crocin treatment improve these changes

Item Type: Article
Uncontrolled Keywords: Crocin, Hypoxia, Passive avoidance memory, Motor activity, Rat
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email gholipour.s@umsu.ac.ir
Date Deposited: 03 Apr 2018 05:35
Last Modified: 13 Feb 2019 07:57
URI: https://eprints.umsu.ac.ir/id/eprint/4552

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