The effect of oral administration of omega fatty acids on lipid peroxidation and oxidative stress enzymes activity in patients with gastric adenocarcinoma after chemotherapy- A double blind clinical trial study

Rasooli, M.S and Dolatkhah, H and Rezazadeh, A (2018) The effect of oral administration of omega fatty acids on lipid peroxidation and oxidative stress enzymes activity in patients with gastric adenocarcinoma after chemotherapy- A double blind clinical trial study. International Journal of Research in Applied and Basic Medical Sciences, 4 (1). pp. 43-52.

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Abstract

Gastric cancer is the fourth most common cancer and the second cause of death in the world. According to the study, gastric cancer cells have a relative resistance to chemotherapy. Therefore, the purpose of this study was to evaluate the effect of oral administration of omega fatty acids PUFAs) on lipid peroxidation and oxidative stress in gastric cancer in people with gastric cancer before and after chemotherapy. Materials & Methods: This is a double-blind clinical trial. The target group was gastric cancer patients who were first identified and under chemotherapy. Among them, 30 were selected and randomly assigned to two groups. they got. In the control group, the treatment was routine with cisplatin plus placebo. In the case group, treatment with cisplatin plus supplemental capsules of Natural Factors Ultimate-Omega Factors with a dose of 1200 mg per day was 3,600 mg Three tablets of 1200 mg (for three courses) started on horizons three weeks. Three samples of stomach biopsy were taken from all patients before and after chemotherapy. Lipid peroxidation was measured by the Thiobarbituric Acid method and the activity of superoxide dismutase and glutathione peroxidase enzymes by Randox kit. To compare the results, Independent- t-test and Mann-Whitney SPSS software. Results: In the case group, the percentage of lipid peroxidation of the gastric cancer tissue after omega-unsaturated fatty acids increased significantly (P value less than 0.0001). Omega fatty acids caused a significant reduction in the activity of the enzyme superoxide dismutase in the case group was statistically lower than the control group (P value less than 0.0001) Conclusion: The results of this study indicate that the use of omega fatty acids as a complement to cisplatin for controlling gastric cancer can be helpful in increasing the amount of oxidative stress and lipid peroxidation of the gastric cancer tissue in this The study was shown.

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