Abolghasemi, M and Yousefi, T and Ghamari, A.A and Mahmoodpoor, A and Karimian, A and Samadi Kafil, H and Yousefi, M and Jadidi Niaragh, F and Eyvaz, SH and Edalati, M and Bastami, M and Samavarchi Tehrani, S and Targhazeh, N and Majidinia, M and Safa, A and Rameshknia, V and Yousefi, B and Naghizadeh, M (2019) MicroRNAs in breast cancer: Roles, functions, and mechanism of actions. J Cell Physiol. pp. 1-22.
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Abstract
Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients.Herein,wewillreviewtherolesoftheseRNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor‐κ B, phosphoinositide‐3‐kinase/Akt, and extracellular‐signal‐ regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | biomarker, cancer, diagnosis, microRNAs, prognosis, signal pathway |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 20 Jan 2020 09:30 |
| Last Modified: | 20 Jan 2020 09:30 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/5785 |
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