Incidence of malignancy after living kidney transplantation: A multicen-ter study from Iran

Einollahi, B and Rostami, Z and Nourbala, M.H and Lessan Pezeshki, M and Sim Foroosh, N and Nemati, E and Pourfarziani, V and Beiraghdar, F and Nafar, M and Pour Reza Gholi, F and Mazdeh, M.M and Amini, M and Ahmadpour, P and Makhdoomi, K and Ghafari, A and Ardalan, M.R and Khosroshahi, H.T and Oliaei, F and Shahidi, S and Abbaszadeh, S and Fatahi, M.R and Hiedari, F and Makhlogh, A and Azmandian, J and Samimagham, H.R and Shahbazian, H and Nazemian, F and Naghibi, M and Khosravi, M and Monfared, A and Mosavi, S.M and Ahmadi, J and Jalalzadeh, M (2012) Incidence of malignancy after living kidney transplantation: A multicen-ter study from Iran. Journal of Cancer, 3 (1). pp. 246-256.

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Abstract

Malignancy is a common complication after renal transplantation. However, limited data are available on post-transplant malignancy in living kidney transplantation. Therefore, we made a plan to evaluate the incidence and types of malignancies, association with the main risk factors and patient survival in a large population of living kidney transplantation. We conducted a large retrospective multicenter study on 12525 renal recipients, accounting for up to 59% of all kidney transplantation in Iran during 22 years follow up period. All information was collected from observation of individual notes or computerized records for transplant patients. Two hundred and sixty-six biopsy-proven malignancies were collected from 16 Transplant Centers in Iran; 26 different type of malignancy categorized in 5 groups were detected. The mean age of patients was 46.2±12.9 years, mean age at tumor diagnosis was 50.8±13.2 years and average time between transplantation and detection of malignancy was 50.0±48.4 months. Overall tumor incidence in recipients was 2%. Kaposis’ sarcoma was the most common type of tumor. The overall mean survival time was 117.1 months (95% CI: 104.9-129.3). In multivariate analysis, the only independent risk factor associated with mortality was type of malignancy. This study revealed the lowest malignancy incidence in living unrelated kidney transplantation

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