Effect of L-arginine and selenium added to a hypocaloric diet enriched with legumes on cardiovascular disease risk factors in women with central obesity: A randomized, double-blind, placebo-controlled trial

Alizadeh, M and Safaeiyan, A and Ostad Rahimi, A and Estakhri, R and Daneghian, S and Ghafari, A and Gargari, B.P (2012) Effect of L-arginine and selenium added to a hypocaloric diet enriched with legumes on cardiovascular disease risk factors in women with central obesity: A randomized, double-blind, placebo-controlled trial. Annals of Nutrition and Metabolism, 60 (2). pp. 157-168.

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Abstract

We aimed to discover if L -arginine and selenium alone or together can increase the effect of a hypocaloric diet enriched in legumes (HDEL) on central obesity and cardiovascular risk factors in women with central obesity. Methods: This randomized, double-blind, placebo-controlled trial was undertaken in 84 premenopausal women with central obesity. After a 2-week run-in period on an isocaloric diet, participants were randomly assigned to a control diet (HDEL), L -arginine (5 g/day) and HDEL, selenium (200 � g/day) and HDEL or L -arginine, selenium and HDEL for 6 weeks. Cardiovascular risk factors were assessed before intervention and 3 and 6 weeks afterwards. Results: After 6 weeks, L -arginine had significantly reduced waist circumference (WC); selenium had significantly lowered fastingconcentrations of serum insulin and the homeostasis model assessment of insulin resistance index; the interaction between L -arginine and selenium significantly reduced the fasting concentration of nitric oxides (NO x ), and HDEL lowered triglycerides (TG) and WC and significantly increased the fasting concentration of NO x . HDEL reduced high-sensitivity C-reactive protein levels in the first half of the study and returned them to basal levels in the second half. Conclusion: These data indicate the beneficial effects of L -arginine on central obesity, selenium on insulin resistance and HDEL on serum concentrations of NO x and TG

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