A SURVEY ON THE FREQUENCY OF MODERATE AND SEVERE DRUG INTERACTIONS AND DURING OPERATION AMONG ELDERLY PATIENTS WITH CANCER UNDER CHEMOTHERAPY REFERRED TO IMAM KHOMEINI HOSPITAL, ARDEBIL 2015-16

Ageing critical period of human life is the increasing number of noncommunicable diseases such as cancers are predictable cases. In most cases Elderly Patients with cancer
addition to cancer chemotherapy for the treatment of diseases and syndromes associated with cancer of
various medicines that can increase the likelihood of drug interactions, toxicity and side effects are. The
aim of leading the prevalence of moderate and severe drug interactions in the elderly undergoing
chemotherapy in cancer patients referred to Imam Khomeini hospital in Ardebil.
Materials & Methods: Cross - sectional study on 102 elderly people who are aged 60 years and older
was conducted. A list of medications the patient by using medical records, relatives and patient himself
prepared, Drug–drug interactions were screened with Drug Interaction Facts software, version 7.0.5.1.
Potential interactions were graded by levels of severity (severe, moderate) and Onset of action (rapid
and delayed). The data were entered into SPSS software and descriptive statistics were presented.
Results: Of the potential interactions, 72/5% Total drug interactions, 16/7% were classified as major
and 55/9% as moderate. 44/1% is potential drug interactions between dexamethasone and Abitanti. Most
drugs prescribed chemotherapy, adjuvant chemotherapy drugs and drugs used to treat Comorbidities
with warfarin drug interactions.
Conclusion: With increasing scientific knowledge of nurses and doctors from drug interactions,
alternative medicines may interact with other medications and by reducing the number of drugs can limit
the number of drug interactions and consequences of reduced