Spectral doppler analysis of parathyroid adenoma: Correlation between resistive index and serum parathyroid hormone concentration

The purpose of this study was to evaluate the correlation between spectral
wave analyses by measuring the resistive index and serum intact parathyroid hormone (iPTH)
concentration in primary hyperparathyroidism.
SUBJECTS AND METHODS. From March 2008 to April 2012, 46 consecutively registered
patients underwent color and spectral Doppler ultrasonography for determination of
vascularity and vascular resistance of parathyroid adenoma. The color Doppler sonographic
findings were compared with methoxyisobutylisonitrile (MIBI) scintigraphic findings, serum
iPTH concentration, and the volume of the gland.
RESULTS. The mean resistive index in parathyroid adenoma was 0.69 ± 0.12. The study
showed a strong negative relation between resistive index and serum iPTH concentration. There
was a significant negative relation between the volume of the gland and the resistive index.
CONCLUSION. There is a relation between degree of perfusion in parathyroid adenoma
and serum iPTH concentration. Resistive index may be an objective alternative parameter
for determining the vascularity of adenoma for monitoring of response to alcohol ablation
therapy and medical management