Association of interleukin-10, interferon-gamma, transforming growth factor-beta, and tumor necrosis factor-alpha gene polymorphisms with long-term kidney allograft survival

Omrani, D and Mokhtari, M.R and Bagheri, M and Ahmadpoor, P (2010) Association of interleukin-10, interferon-gamma, transforming growth factor-beta, and tumor necrosis factor-alpha gene polymorphisms with long-term kidney allograft survival. Iranian Journal of Kidney Diseases, 4 (2). pp. 141-146.

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Abstract

Single nucleotide polymorphisms within promoter or other regulatory sequences of cytokine genes mainly influence the level of production and secretion of proteins. A large amount of evidence has shown that cytokine gene variations alter graft survival length after kidney transplantation. We studied the association of gene polymorphisms in the interlekin-10 gene (IL10; -1082 G/A), interferon-γ gene (IFNG; +874 T/A), transforming growth factor-β gene (TGFB; +869 T/C), and tumor necrosis factor-α gene (TNFA; -308 A/G) with kidney allograft survival. Materials and Methods. The IL10 (-1082 G/A), IFNG (+874 T/A), TGFB (+869 T/C), and TNFA (-308 A/G) genotypes were determined in 32 kidney allograft recipients with graft rejection during the 1st posttransplant year and 52 without rejection in 5 posttransplant years, using allele-specific oligonucleotides-polymerase chain reaction method. Results. The IFNG +874 A/T genotype showed a significantly higher frequency among kidney recipients of the rejection group than the control group (odds ratio, 2.64, 95% confidence interval, 1.03 to 6.74; P = .04). Comparisons between the rejection and control groups in IL10 (-1082 G/A), IFNG (+874 T/A), TGFB (+869 T/C), and TNFA (-308 A/G) single nucleotide polymorphisms showed no significant difference. Conclusions. Based on the finding of this study, it seems polymorphisms in the genes that regulate IL-10, IFN-γ, TGF-β, and TNF-α cytokines do not play a major role in kidney allograft survival, and other potential factors in this regard should be considered.

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