Rezaei, R and Sadraie, S.H and Kaka, GH.R and Mofid, M and Hassanzadeh, Z (2014) HISTOMORPHOMETRIC AND IMMUNOHISTOCHEMICAL EVALUATION OF CELL TRANSPLANTATION ON THE REPAIR OF BONE DEFECTS IN RAT. The Journal of Urmia University of Medical Sciences, 25 (5). pp. 414-424.
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Abstract
Bone marrow stromal cells (BMSCs) are multipotent stem cells that can proliferate and differentiate into osteogenic cells. This study aimed to investigate the effects of BMSCs transplantation for the repair of bone defects in rat. Materials & Methods: In this study twenty-eight male adult rats were equally divided into 4 groups. Group 1 (control group) received no treatment after bone defect; after bone defect the culture medium was injected at the site of bone defect for group 2 (sham group); group 3 was non-autologous cell transplantation group and group 4 was autologous cell transplantation group. Bone histomorphometric evaluations and cell counting were performed in all groups. Results: No significant differences were found between the control group and Sham according to histomorphometric study. The mean trabecular surface was significantly increased in autologous and non-autologous groups compared to the control group. In addition, mean number of osteocytes was increased in autologous and non-autologous groups when compared to the control group. Conclusion: It seems that both autologous and non-autologous BMSCs transplantation appears to be effective in the repair of bone defect.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BMSCs, Cell transplantation, Bone repair, Rat |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 08 Nov 2017 05:04 |
| Last Modified: | 30 Jun 2019 03:37 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/3271 |
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