PREVALENCE OF POTENTIAL DRUG INTERACTIONS IN PATIENTS IN THE INTENSIVE CARE UNIT OF URMIA TALEGHANI HOSPITAL

Rahimi, B and Gharabaghi, N and Hesari, Z and Balanj, SH and Alinia, T (2013) PREVALENCE OF POTENTIAL DRUG INTERACTIONS IN PATIENTS IN THE INTENSIVE CARE UNIT OF URMIA TALEGHANI HOSPITAL. The Journal of Urmia University of Medical Sciences, 24 (2). pp. 133-145.

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Abstract

Potential Drug Interaction (PDI) is one of the medicine error which can led to undesirable reactions in patients. PDI occures when effect of toxocity of one medicine is affected by another one. This study aims to examination of of PDI freguency, clinical value ranking and risk factors in ICU ward of Urmia Taleghani hospital, Iran in 2011. Materials & Methods: A cross-sectional study was carried out amog 193 inpatient of ICU ward. Data were collected retrospectively. Descriptive-analytical methods was used to analyse data including mean, median, standard deviation and t-test. Data were anlysed by SPSS. Results: Frequency of PDI was 73.6% and mean of PDI was 4.07. The most common PDI was Ranitidin + Midozolam with 26 (4.1%) of cases. grade of PDI was mild for 46 (7.9%), moderate for 192 (33%), sever for 51(8.8%), contradicted for 150 (25.8%), (), and unknown for 143 (24.4%). PDI effects manifested immediately for 195 (33.5%) and with delay for 384 (66.5%). 49.95 % of PDIs had significant clinical value and 41.19 % higly significant clinical value. Conclusion: Knowledge of drug interaction, replacing of interacting drug with other drugs as much as possible, noticing of highly interacting drugs, deminishing number of prescribed drugs can reduce PDI number and its consequences.

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