PREVALENCE OF POTENTIAL DRUG INTERACTIONS IN PATIENTS IN THE INTENSIVE CARE UNIT OF URMIA TALEGHANI HOSPITAL

Potential Drug Interaction (PDI) is one of the medicine error which can led to
undesirable reactions in patients. PDI occures when effect of toxocity of one medicine is affected by
another one. This study aims to examination of of PDI freguency, clinical value ranking and risk
factors in ICU ward of Urmia Taleghani hospital, Iran in 2011.
Materials & Methods: A cross-sectional study was carried out amog 193 inpatient of ICU ward. Data
were collected retrospectively. Descriptive-analytical methods was used to analyse data including
mean, median, standard deviation and t-test. Data were anlysed by SPSS.
Results: Frequency of PDI was 73.6% and mean of PDI was 4.07. The most common PDI was
Ranitidin + Midozolam with 26 (4.1%) of cases. grade of PDI was mild for 46 (7.9%), moderate for
192 (33%), sever for 51(8.8%), contradicted for 150 (25.8%), (), and unknown for 143 (24.4%). PDI
effects manifested immediately for 195 (33.5%) and with delay for 384 (66.5%). 49.95 % of PDIs had
significant clinical value and 41.19 % higly significant clinical value.
Conclusion: Knowledge of drug interaction, replacing of interacting drug with other drugs as much as
possible, noticing of highly interacting drugs, deminishing number of prescribed drugs can reduce PDI
number and its consequences.