Ghorbanzade, A and Shahabi, P and Pakdel, F.G and Ebrahimi, H and Sadighi, M and Oskouei, B.S and Yousefi, H (2015) Effect of metabotropic glutamate receptors II /III agonists on spike-wave discharge in primary somatosensory perioral cortex of male WAG/Rij rats. Biosciences Biotechnology Research Asia, 12. pp. 65-70.
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Abstract
The aim of this study was investigation of metabotropic glutamate receptors II/ III on spike-and-wave discharges in perioral somatosensory cortex of male WAG/Rij rats. Eighteen male WAG/Rij rats was used in this experiment. Rats anesthetized with a combination of ketamine and xilusinip and 2 μl of drugs injected with a 10 μl Hamilton syringe bilaterally. At the end of the experiment, all animals were killed by high dose of ketamine. The brain was removed rapidly and fixed in 10% formalin. Cresyl violet stained coronal sections were viewed with a light microscope to verify cannula placement. In all groups mean numbers and mean duration of Spike-and-wave discharges was decreased, but peak frequency was only in L-AP4 group was reduced. These agonists are able to suppress epileptic discharges in WAG/Rij rats and could be useful for treatment of Absence epilepsy in the future
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | Metabotropic, Glutamate, WAG/Rij, Spike-and-wave, Perioral somatosensory cortex. |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 22 Jul 2017 04:15 |
| Last Modified: | 04 Feb 2019 05:32 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/377 |
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