RELATIONSHIP BETWEEN XANTHINE OXIDASE AND LUTATHIONE PEROXIDASE ENZYMES WITH CORONARY ARTERY DISEASE

Nourooz Zadeh, J and Ashori, S and Valipour, M and Khadem Vatani, K and Mohammadzadeh, M.H (2018) RELATIONSHIP BETWEEN XANTHINE OXIDASE AND LUTATHIONE PEROXIDASE ENZYMES WITH CORONARY ARTERY DISEASE. The Journal of Urmia University of Medical Sciences, Vol. 29(1), April 2018, 29 (1). pp. 33-38.

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Abstract

Considering the high prevalence of cardiovascular disease among people in the world, the aim of this study was to simultaneously investigate the association between the serum level of xanthine oxidase and glutathione peroxidase enzymes with the severity of coronary artery disease. Materials & Methods: In this case-control study, 85 patients undergoing coronary artery angiography participated and were divided in to the three groups considering the results of angiography by Syntax score as follows: 1. without coronary artery disease (Syntax score = 0); 2. Mild coronary artery disease (Syntax score˂ 22); 3. severe coronary artery disease (Syntax score ≥22). XO was measured by ELISA method and GPX activity assay by Coupled assay. The results were compared using SPSS software version 16. Results: Our results showed that the control group had ejection fraction higher than the other two groups, and the EF was an independent risk factor for the incidence of coronary artery disease (OR = 0.349, P = 0.001). There was a significant difference between the three groups in terms of history of myocardial infarction (OR = 0.332, P = 0.11). Also serum total cholesterol levels were significantly different between the groups (OR = 0.400 and P=0.030). XO value was significantly higher in patients with severe coronary artery stenosis than the other groups but the difference was not statistically significant (P = 0.206). Moreover, with increasing severity of vascular arrest, the level of GPX serum reduced (P =0.539). Conclusion: Overall, our results indicated that there are no independent correlation between XO and GPX factors with the severity of arterial obstruction

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