Farjah, G.H and Khadem Ansari, M.H and Salehi, S.H and Pourheidar, B (2017) Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats. Iran J Basic Med Sci, 20. pp. 334-337.
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Abstract
Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. Results: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P<0.001). Saffron extract groups significantly decreased plasma level of malondialdehyde than in the NS Group (P<0.05). The number of motor normal neurons was significantly greater in the high saffron extract group than in the NS and low saffron group (P<0.05). Conclusion: These data suggest that a saffron extract may protect spinal cord neurons from I/R injury
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Ischemia Reperfusion Spinal cord Saffron extract |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 19 Aug 2018 05:40 |
| Last Modified: | 01 Jul 2019 05:09 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/4998 |
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