Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats

Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In
this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury.
Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham
surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract.
Results: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract
groups than in the NS group at 48 hr after spinal cord ischemia (P<0.001). Saffron extract groups
significantly decreased plasma level of malondialdehyde than in the NS Group (P<0.05). The number of
motor normal neurons was significantly greater in the high saffron extract group than in the NS and
low saffron group (P<0.05).
Conclusion: These data suggest that a saffron extract may protect spinal cord neurons from I/R injury