Serum levels of selenium and copper in an Iranian elderly women diagnosed type‐1 diabetes mellitus and correlations with diabetic complications

Bamdadi Kalurazi, E and Rostaminasab, S and Mohammadian, M and Darvishi, S and Toofani Milani, A and Zeinaly, Sh and Javandust, F and Fathi younesi, F and Rashidi, S (2016) Serum levels of selenium and copper in an Iranian elderly women diagnosed type‐1 diabetes mellitus and correlations with diabetic complications. International Journal of Advanced and Applied Sciences, 3 (6). pp. 49-52.

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Abstract

Type 1 diabetes mellitus (T1DM) is an autoimmune disease which correlated with various Miscellaneous factors. Environmental and genetic factors and oxidative stress-induced free radicals may have a role in the pathogenesis of this complex disorder. Trace element such as selenium and copper are involved in an antioxidant defense that may play a role in T1DM complications, so in this study we evaluate the two major trace elements (selenium, copper) status in T1DM patients and their probable relationships with diabetic complications. In a case-control study concluded 68 female patients with T1DM in compared with 122 healthy female individuals, Fasting plasma samples were analyzed for fasting blood sugar (FBS), fructose amine, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TGs), serum copper and selenium concentrations were measured by flame atomic absorption spectrophotometry. Statistical analysis was performed with SPPS software. Based on our data, in patient group, mean copper and selenium concentration were lower in compared to healthy controls (p>0.05) dyslipidemia was found in a significantly higher percentage of women with T1DM compared to that of the non-diabetic control group. Overall in patients group the majority of the dyslipidemia subjects had suboptimal glycemic status and lower level of selenium. Lipid disorders in women with T1DM may be present regardless of their metabolic control that found that poorer glycemic control is related to higher serum lipids levels and lower plasma selenium status. Indeed Dyslipidemia and poorer glycemic status was significantly more frequent among females with selenium deficiency.

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