Serum levels of selenium and copper in an Iranian elderly women diagnosed type‐1 diabetes mellitus and correlations with diabetic complications

Type 1 diabetes mellitus (T1DM) is an autoimmune disease which correlated
with various Miscellaneous factors. Environmental and genetic factors and
oxidative stress-induced free radicals may have a role in the pathogenesis of
this complex disorder. Trace element such as selenium and copper are
involved in an antioxidant defense that may play a role in T1DM
complications, so in this study we evaluate the two major trace elements
(selenium, copper) status in T1DM patients and their probable relationships
with diabetic complications. In a case-control study concluded 68 female
patients with T1DM in compared with 122 healthy female individuals,
Fasting plasma samples were analyzed for fasting blood sugar (FBS), fructose
amine, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C),
high-density lipoprotein cholesterol (HDL-C), triglyceride (TGs), serum
copper and selenium concentrations were measured by flame atomic
absorption spectrophotometry. Statistical analysis was performed with SPPS
software. Based on our data, in patient group, mean copper and selenium
concentration were lower in compared to healthy controls (p>0.05)
dyslipidemia was found in a significantly higher percentage of women with
T1DM compared to that of the non-diabetic control group. Overall in patients
group the majority of the dyslipidemia subjects had suboptimal glycemic
status and lower level of selenium. Lipid disorders in women with T1DM may
be present regardless of their metabolic control that found that poorer
glycemic control is related to higher serum lipids levels and lower plasma
selenium status. Indeed Dyslipidemia and poorer glycemic status was
significantly more frequent among females with selenium deficiency.