The Effect of Curcumin on Functional and Structural Alterations of the Liver in Rats after MDMA Consumption

Khalaji, N and Pourheydar, M and Bagheri, M and Chodari, L and Dindarian, S and Hasanpour, M and Khadem Ansari, M.H (2019) The Effect of Curcumin on Functional and Structural Alterations of the Liver in Rats after MDMA Consumption. Journal of KermanUniversity ofMedical Sciences, 2019; 26 (6): 461-472, 26 (6). pp. 461-472.

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Abstract

Nowadays, one of the problems of human beings is drug addiction, which causes individual,economicand socialdamages.Oneof themost commonlyused substances in parties is ecstasy pills or 3, 4-methylenedioxymethamphetamine (MDMA). This study seeks to assess the effect of curcumin in complications of ecstasy on liver tissue in rats. 48 maleWistar rats in six groupswere treated with curcumin (20 µ mol/kg) and MDMA (20mg/kg) simultaneously and non-simultaneously.At the end of the experiment, blood sampleswere collected, lipidprofile, liver enzymesweremeasured andmorphologyof liverwas done. MDMAconsumptionhad adverse effect on lipidprofile in comparison to the control group.Treatmentof curcuminwithMDMA consumption improved thiseffect ofMDMAon lipid profile.Moreover,curcumin treatment concurrentwithMDMA consumption increased liver enzymes, whereas consumption ofMDMA for 15 days and curcumin treatment in the next 15 days decreased liver enzymes. Our findings suggest that simultaneous consumption ofMDMA and curcumin have a synergistic adverse effect on liver enzymes and liver tissue. It is assumed thatMDMA intestinal absorption increased by curcumin.While non-simultaneous treatment of curcumin andMDMA improved undesirableeffects ofMDMAon liver that is assumed by antioxidant capabilities of curcumin

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