Almohammai, A and Rezaie, J and Ahmadi, M and Keyhanmanesh, R and Rahbarghazi, R (2021) Asthmatic condition induced the activity of exosome secretory pathway in rat pulmonary tissues. Journal of Inflammation, 18. pp. 14-22.
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Abstract
The recent studies highlighted the critical role of exosomes in the regulation of inflammation. Here, we investigated the dynamic biogenesis of the exosomes in the rat model of asthma. Results: Our finding showed an increase in the expression of IL-4 and the suppression of IL-10 in asthmatic lung tissues compared to the control samples (p < 0.05). Along with the promotion of IL-4, the protein level of TNF-α was induced, showing an active inflammatory status in OVA-sensitized rats. According to our data, the promotion of asthmatic responses increased exosome biogenesis indicated by increased CD63 levels and acetylcholine esterase activity compared to the normal condition (p < 0.05). Conclusion: Data suggest that the stimulation of inflammatory response in asthmatic rats could simultaneously increase the paracrine activity of pulmonary cells via the exosome biogenesis. Exosome biogenesis may correlate with the inflammatory response
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Asthma, Exosome biogenesis, CD63, Inflammatory cytokines, Rats |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 07 Jun 2021 04:27 |
| Last Modified: | 07 Jun 2021 04:27 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/6235 |
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