Asthmatic condition induced the activity of exosome secretory pathway in rat pulmonary tissues

The recent studies highlighted the critical role of exosomes in the regulation of inflammation. Here,
we investigated the dynamic biogenesis of the exosomes in the rat model of asthma.
Results: Our finding showed an increase in the expression of IL-4 and the suppression of IL-10 in asthmatic lung
tissues compared to the control samples (p < 0.05). Along with the promotion of IL-4, the protein level of TNF-α
was induced, showing an active inflammatory status in OVA-sensitized rats. According to our data, the promotion
of asthmatic responses increased exosome biogenesis indicated by increased CD63 levels and acetylcholine
esterase activity compared to the normal condition (p < 0.05).
Conclusion: Data suggest that the stimulation of inflammatory response in asthmatic rats could simultaneously
increase the paracrine activity of pulmonary cells via the exosome biogenesis. Exosome biogenesis may correlate
with the inflammatory response