Sadighi, M and Shahabi, P and Oryan, S and Pakdel, F.G and Asghari, M and Pshapour, A (2013) Effect of low frequency electrical stimulation on spike and wave discharges of perioral somatosensory cortex in WAG/Rij rats. Pathophysiology, 20 (3). pp. 171-176.
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Abstract
Lowfrequencyelectricalstimulationhasbeenrevealedthatasapotentialcureinpatientwithdrugresistanttoepilepsy.Thisstudytriesto evaluatetheeffectoflowfrequencyelectricalstimulation(LFS)onabsenceseizureofperioralregionprimarysomatosensorycortex(S1po). Eighteen maleWAG/RijratswerereceivedLFS(3Hz,squarewave,monophasic,200 �s, and400�A) for25minintoS1poforaperiodof fivedays.Thereis6animalspergroup.ThestimulatingelectrodeswereimplantedaccordingtostereotaxiclandmarksandEEGrecordingwas obtained 30minbeforeandafterLFStoanalysefrequency,numberanddurationofspike–wavedischarges(SWD).Theresultsshowedthatin animals withunilateralstimulatingelectrodes(Exp1)infirstandseconddaysandalsoinanimalswithbilateralstimulatingelectrodes(Exp2) in days3rdand4th.LFShadsignificantdecreaseeffects(p < 0.05)onmeannumberofSWDbetweenpre-LFS.Incomparisonpre-LFSto post-LFS, meanofdurationinExp2decreasedsignificantly.IncontinuousapplicationofLFS(5days)onlythedataoffirstdaywasdifferently significant (p < 0.05)butdataofotherdayshadnodifference.ComparisonofdatabetweenExp1,Exp2andcontrolgroupsshowedthatthe mean numberofExp1wassignificantlydifferent(p < 0.05)andmeanpickfrequencyinExp2wassignificantlydecreasedincomparisonwith Exp1 group(p < 0.05).TheLFSofS1poproducessignificantantiepilepticeffectonabsenceseizurebutitwasnotpersistenttillthenextday and showsashorttimeeffect
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 4 |
| Uncontrolled Keywords: | Absence seizure;Perioralsomatosensorycortex;Spike–wavedischarges(SWD);WAG\Rij rat |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 30 Jul 2017 08:34 |
| Last Modified: | 25 Jun 2019 04:18 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/814 |
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