MANUFACTURE OF NANO-FIBERS ELECTROSPUN POLYAMIDOAMINES CONTAINING DOXORUBICIN

Ayoubi, S and Hashemzadeh, M.S (2016) MANUFACTURE OF NANO-FIBERS ELECTROSPUN POLYAMIDOAMINES CONTAINING DOXORUBICIN. The Journal of Urmia University of Medical Sciences, 27 (6). pp. 486-493.

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Abstract

Doxorubicin sold under the trade names Adriamycin is an anticancer drug that interferes with the growth and spread of cancer cells in the body. The purpose of this study was to produce nano-fibers, polyamide amine (PAMAM) containing Doxorubicin drug using electrospinning technique. Materials & Methods: This cross-sectional study was conducted in the Faculty of Pharmacy in Tehran University of Medical Sciences, from 2014 to 2015. In the this study, concentration of PAMAM in ethanol, ratio of drug to polymer, Voltage and output current intensity as independent variables, and the diameter of the fibers produced as the dependent variable were selected and studied. Then using the SPSS software, equation of producing nano-fibers were evaluated and the polymer films containing drug by SEM attention of the morphologic, and the diameter of the fibers and the FTIR were studied both physically and chemically. Results: According to the FT-IR of drug with the polymer After the electrospinning process, it was revealed that neither of these two materials lost their properties during electrospinning, and no chemical change was observed in their structure. Conclusion: Provided that the solution concentration and the ratio of drug to polymer reduces, defective fibers will be formed, and further reduction of these two parameters will lead to formation of micro and nano particles

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