EVALUATION OF ANTIOXIDANT ACTIVITY OF KLOTHO IN HEMODIALYSIS PATIENTS AND RENAL TRANSPLANT RECIPIENTS

Ghazizadeh, T and Ghorbani Haghjo, A and Arghani, H and Raeisi, S and Safa, J and Aliasgari, J and Rashtchizadeh, N (2015) EVALUATION OF ANTIOXIDANT ACTIVITY OF KLOTHO IN HEMODIALYSIS PATIENTS AND RENAL TRANSPLANT RECIPIENTS. The Journal of Urmia University of Medical Sciences, 26 (9). pp. 743-753.

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Abstract

The aim of this study was to evaluate serum levels of antioxidant property Klotho by examining 8-hydroxy-2'- deoxyguanosine (8-OHdG), as a marker of oxidative damage in nucleic acids in patients with hemodialysis and kidney transplantation. Materials & Methods: Serum samples from 45 patients undergoing hemodialysis and 45 patients with stable renal transplant recipients were collected. Klotho levels, 8OHdG, iPTH and vitamin D (25 (OH) D) were measured using standard methods. Results: Klotho level in hemodialysis patients was significantly higher (p≤0.001). Considering the serum levels (8-OHdG), there was no significant difference between the two groups (p=0.242). Serum parathyroid hormone levels in hemodialysis patients was significantly higher while the correlation between serum levels of iPTH and Klotho in none of the two groups were observed. Conclusion: It seems that high levels of Klotho in hemodialysis patients is a secondary response to high levels of parathyroid hormone, or just due to the use of immunosuppressive drugs in renal transplant recipients

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