EVALUATION OF ANTIOXIDANT ACTIVITY OF KLOTHO IN HEMODIALYSIS PATIENTS AND RENAL TRANSPLANT RECIPIENTS

The aim of this study was to evaluate serum levels of antioxidant property Klotho
by examining 8-hydroxy-2'- deoxyguanosine (8-OHdG), as a marker of oxidative damage in nucleic
acids in patients with hemodialysis and kidney transplantation.
Materials & Methods: Serum samples from 45 patients undergoing hemodialysis and 45 patients with
stable renal transplant recipients were collected. Klotho levels, 8OHdG, iPTH and vitamin D (25 (OH)
D) were measured using standard methods.
Results: Klotho level in hemodialysis patients was significantly higher (p≤0.001). Considering the
serum levels (8-OHdG), there was no significant difference between the two groups (p=0.242). Serum
parathyroid hormone levels in hemodialysis patients was significantly higher while the correlation
between serum levels of iPTH and Klotho in none of the two groups were observed.
Conclusion: It seems that high levels of Klotho in hemodialysis patients is a secondary response to high
levels of parathyroid hormone, or just due to the use of immunosuppressive drugs in renal transplant
recipients