ASSESSMENT OF THE DEMOGRAPHIC DATA AND EXPRESSION OF THE CELLULAR MARKERS CD20, CD30, CD15 IN REEDSTERNBERG CELLS, ALONG WITH THEIR RELATION TO STAGING IN HODGKIN LYMPHOMA CASES OF IMAM KHOMEINI HOSPITAL OF URMIA CITY

Iilkhanizadeh, B and Mazlomi, P and Eishi Oskuie, A and Yekta, Z (2013) ASSESSMENT OF THE DEMOGRAPHIC DATA AND EXPRESSION OF THE CELLULAR MARKERS CD20, CD30, CD15 IN REEDSTERNBERG CELLS, ALONG WITH THEIR RELATION TO STAGING IN HODGKIN LYMPHOMA CASES OF IMAM KHOMEINI HOSPITAL OF URMIA CITY. The Journal of Urmia University of Medical Sciences, 24 (2). pp. 146-153.

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Abstract

Staging plays an important role both in defining the prognosis of Hodgkin disease and choosing the best treatment regimen. Moreover, factors such as age, gender, WBC>15000, Hb<10.5mg/dl, and B-symptoms has been also recommended to be influential in the prognosis, which were not completely successful. Nevertheless many studies have investigated the correlation between cellular markers and the prognosis of Hodgkin lymphoma. Among them, CD15, CD30 and CD15 were the most studied markers. In this study we evaluated both the demographic findings and frequencies of expression of the markers CD20, CD30, CD15 and their relation to Staging in Hodgkin lymphoma cases of Imam Khomeini hospital of Urmia, Iran. Materials & Methods: Retrospectively 66 eligible patients from 2005 to 2010 entered the study. For evaluation of the markers CD20, CD30, CD15, Immunohistochemistery preformed on lymph-nods’ paraffin embedded blocks. Staging, demographic findings and Immunohistochemical findings analyzed for possible correlation between Staging and other parameters. In all cases SPSS software and Fisher Exact test were used for statistical analyzes. Results: In our study, median age of patients was 30.6±17 years old and 54.5% of patients were admitted with higher stages of the disease, which is similar to results of other studies in the country. Respectively, 63.6%, 90.9% and 18.2% of cases expressed cellular markers CD15, CD30 and CD20. Conclusion Furthermore, statistical analysis revealed that CD15 was inversely correlated with disease stage. (P= 0.027). In contrast, we didn’t find any relation between Staging with neither CD20 nor CD30 positivity that possibly offers the latter markers were not related to disease prognosis.(P= 0.482, P= 0.376).

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