STUDY OF EFFECTS OF ALBENDAZOLE SULFOXIDE ON OBVIATION OF ECHINOCOCCUS GRANULOSUS PROTOSCOLEXES.

Hazrati Tappeh, KH and Musavi, S.J and Aghazadeh Attari, J (2008) STUDY OF EFFECTS OF ALBENDAZOLE SULFOXIDE ON OBVIATION OF ECHINOCOCCUS GRANULOSUS PROTOSCOLEXES. J Urmia Univ Med Sci., 19 (2). pp. 120-124.

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Abstract

Parasitic infection of the liver and lungs derived from hydatid cyst is global and it can affect many organs of the body, it encompasses lots of significance. This disease can abide many phenomena its treatment is very expensive and has its own troubles. Recognition of diagnostic methods and mostly, treatment of hydatid cyst according to almost high prevalence of the disease does play an important role on controlling the disease. The definite treatment is surgery. But as a complimentary cure, at present albendazole is the most effective drug for hydatid cyst. After utilization, albendazole fastly absorbs and catalyses to sulfoxide which is the major metabolite of the drug. The goal of this study is to analyze the efficiency of albendazole sulfoxide on different densities and time intervals, in vitro on protoscolexes. Materials & Methods: This study was conducted interventionally and tentatively. After detachment of hundreds of hydatid cyst infected animals from abattoirs and after enough investigation on productivity of cysts, their protoscolexes were evacuated and were washed with serum physiology and their viability rate was examined under the microscope. On the other side albendazole sulfoxide solution on 25µg/L, 50µg/lit, 100µg/lit densities was prepared. Then precise amount of protosclolexes was added to tubes containing sulfoxide and examinations were done in different time intervals. On the next stage their percentage of survival using microscope according to movements of flame like cells were determined and recorded. Results: Results revealed that time and the amount of drug has straight effects on protoscolexes survival time. In the group that 100µg/L albendazole was used, the drug had no effect up to first 20 minutes but increasing the gain age time to 1hour 60% of protoscolexes were dead. While in the density of 50µg/lit up to 35minutes, the drug did have no effect, but in an hour 40% of protoscolexes were dead. Conclision: According to the results this study and time limitations that surgeons have in operation room, albendazole sulfoxide can not be utilized to eliminate protoscolexes from patients infected organs in the op. process and to avoid recurrence of the illness.

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