EFFECTS OF HELICOBACTER PYLORI INFECTION ON CATALASE, PROTEIN CARBONYL IN PATIENTS WITH CHRONIC GASTRITIS

Ashraf Rezaee, N and Sohrabi, N and Khadem Ansari, M.H (2015) EFFECTS OF HELICOBACTER PYLORI INFECTION ON CATALASE, PROTEIN CARBONYL IN PATIENTS WITH CHRONIC GASTRITIS. The Journal of Urmia Nursing and Midwifery Faculty, 13 (4). pp. 253-259.

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Abstract

Helicobacter pylori is a gram-negative bacterium that causes damage to the stomach lining, and it cause digestive problems. Several mechanisms have been proposed for the pathogenesis such as producing alkaline conditions by urease enzyme and oxidative stress. Oxidative stress is essentially an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants. An important factor for the evaluation of oxidant and antioxidant is the catalase and protein carbonyl content. The aim of this study was to determine the status of these two factors in individuals infected by H. pylori. Materials & Methods: After sampling and determination of infection status, protein carbonyl and catalase activity were measured. The survey data were analyzed by using spss software. Results: 68 out of 150 suspected cases were infected with H. pylori. Catalase and protein carbonyl levels were significantly higher in these cases comparing to the controls. Conclusions: Increased protein carbonyl content confirms oxidative damage by H. pylori, and catalase activity increases in response to the stress and oxidative damage

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