THE EFFECT OF ETHANOL ON PLASMA CERULOPLASMIN LEVEL AND CAMKII IN RATS'S HEART

Heshmati, E and Alizadeh, M (2018) THE EFFECT OF ETHANOL ON PLASMA CERULOPLASMIN LEVEL AND CAMKII IN RATS'S HEART. The Journal of Urmia University of Medical Sciences, 28 (10). pp. 629-636.

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Abstract

Chronic alcohol consumption has been associated with cardiovascular abnormalities, including cardiomyopathy, hypertension, coronary artery disease, and stroke. Although the association between chronic alcohol intake and cardiac abnormality is well-known, the exact underlying molecular mediators involved in alcohol-induced heart abnormalities remain elusive. The aim of this study was to investigate the effect of chronic alcohol intake on plasma ceruloplasmin level and calcium /calmodulin-depedent protein kinase II in male Wistar rats' heart. Materials & Method: Sixteen male Wistar rats were divided into two groups, control and ethanol groups. Rats in the ethanol group received ethanol with a dose of 4.5 g/kg body weight saluted in tap water (20% w/v) and administrated intragastrically by gavage once a day. After six weeks of treatment, plasma ceruloplasmin level and CaMKII of heart tissue were measured. Results: Although the results revealed an increase in CaMKII amount in the ethanol group, compared to that in the control group, it did not reach statistical significance (P-value: 0.75). In addition, there was no significant difference between plasma ceruloplasmin level in the ethanol group and control group (Pvalue=0.993). Conclusions: According to results of the current study, although both CaMKII and ceruloplasmin have well known impact on cardiovascular abnormalities, they cannot be considered as molecular mediators involved in alcohol-induced heart disorders

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