Kaviani, M and Mirza Aghazadeh Attari, M and Ghazizadeh Darband, S and Aghazadeh Attari, J and Mihanfar, A and Yousefi, B and Majidini, M (2018) DNA damage response and repair in colorectal cancer: Defects, regulation and therapeutic implications. DNA Repair, 69. pp. 34-52.
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Abstract
DNA damage response, a key factor involved in maintaining genome integrity and stability, consists of several kinase-dependent signaling pathways, which sense and transduce DNA damage signal. The severity of damage appears to determine DNA damage responses, which can include cell cycle arrest, damage repair and apoptosis. A number of recent studies have demonstrated that defection in signaling through this network is thought to be an underlying mechanism behind the development and progression of various types of human malignancies, including colorectal cancer. In this review, colorectal cancer and its molecular pathology as well as DNA damage response is briefly introduced. Finally, the involvement of key components of this network in the initiation/ progression, prognosis, response to treatment and development of drug resistance is comprehensively discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DNA damage response DNA repair Colon cancer Apoptosis Cell cycle checkpoint |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 14 Oct 2018 06:55 |
| Last Modified: | 01 Jun 2019 05:00 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/5203 |
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